Publications

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Browse the full publication list; filter by category or year. For topic‑based curation, see Research to find some of our seminal papers organized by our main areas of focus. Our research is published in journals such as Cell, Nature Cancer, Nature Genetics, JAMA Oncology, JCO, Nature, Lancet, Clinical Cancer Research, and JNCI, among others.

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Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial

Park W, O'Connor C, Chou J, Hilmi M, Tarcan Z, Schwartz C, Larsen M, Chatila W, Sivaprakasam K, Umeda S, Perry M, Varghese A, Yu K, Balogun F, Zervoudakis A, Katz S, Kim TH, Zhao K, Richards A, Lecomte N, Muldoon D, Karnoub E, Yang J, El Dika I, Rao D, Smita J, Foote M, Sugarman R, Harding J, Epstein A, Kelsen D, Chalasani S, Keane F, Schoenfeld J, Singhal A, Diguglielmo E, Bandlamudi C, Song J, Ozkan HS, Hong J, Zhang H, Cardenas A, Lao M, Melchor J, Shah R, Kang W, Mazzoni F, Soares K, Donoghue M, Balachandran V, Schattner M, Santos E, Rolston V, Reyngold M, Wei A, Homsi R, Tipping M, Basturk O, Berger M, Do R, Jarnagin W, Riaz N, Pe'er D, Capanu M, Iacobuzio-Donahue C, O'Reilly E · Res Sq [Preprint]. 2025 Sep 1:rs.3.rs-7334701. doi: 10.21203/rs.3.rs-7334701/v1. PMID: 40951294; PMCID: PMC12425079.

Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial

Tumor Upstaging With MRI for HPV-Associated Oropharynx Cancer: Implications for De-Escalation Trials

Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level

Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancer

AlphaMissense for Identifying Pathogenic Missense Mutations in DNA Damage Repair Genes in Cancer

Optimizing Outcomes After Transoral Robotic Surgery for Oropharyngeal Carcinoma: Reflections on the ASCO Guideline

Outcomes of Reduced Elective Nodal Radiation Dose and Volume for Laryngeal, Hypopharyngeal, and p16-Negative Oropharyngeal Cancers

Long-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Predicting and monitoring response to head and neck cancer radiotherapy using multimodality imaging and radiobiological digital twin simulations

The cold immunological landscape of ATM-deficient cancers

RNA transcripts serve as a template for double-strand break repair in human cells

Impact of Clonal Hematopoiesis on Solid Tumor Progression Following Radiation Therapy

Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab

Tumor Hypoxia on 18F-fluoromisonidazole Positron Emission Tomography and Distant Metastasis From Head and Neck Squamous Cell Carcinoma

Impact of Surveillance Imaging in Patients With HPV-Associated Oropharyngeal Carcinoma Treated With Definitive Radiation and Chemotherapy

Development of 18F-Fluoromisonidazole Hypoxia PET/CT Diagnostic Interpretation Criteria and Validation of Interreader Reliability, Reproducibility, and Performance

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

Micronuclear collapse from oxidative damage

Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors

Optimal systemic treatment and real-world clinical application of ctDNA in patients with metastatic HER2-mutant lung cancer

Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy

A Genomics-Driven Artificial Intelligence- Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms

Multi-modality imaging parameters that predict rapid tumor regression in head and neck radiotherapy

Increased Synthetic Cytotoxicity of Combinatorial Chemoradiation Therapy in Homologous Recombination Deficient Tumors

Reply to A.S

An Analysis of Positron Emission Tomography Maximum Standard Uptake Value Among Patients With Head and Neck Cancer Receiving Photon and Proton Radiation

Multi-scale geometric network analysis identifies melanoma immunotherapy response gene modules

Auto-segmentation of neck nodal metastases using self-distilled masked image transformer on longitudinal MR images

Clinical Experience With an Offline Adaptive Radiation Therapy Head and Neck Program: Dosimetric Benefits and Opportunities for Patient Selection

Hypoxia-Directed Treatment of Human Papillomavirus-Related Oropharyngeal Carcinoma

Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study

Multi-Scale Geometric Network Analysis Identifies Melanoma Immunotherapy Response Gene Modules

Most large structural variants in cancer genomes can be detected without long reads

An essential goal within reach: attaining diversity, equity, and inclusion for the Journal of the National Cancer Institute journals

An essential goal within reach: attaining diversity, equity, and inclusion for the Journal of the National Cancer Institute journals

Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial

Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma

Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers

Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma

Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer

Stem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironment

Post-operative PET/CT improves the detection of early recurrence of squamous cell carcinomas of the oral cavity

Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

Impact of immune infiltration signatures on prognosis in endometrial carcinoma is dependent on the underlying molecular subtype

Evaluation of Proton Therapy Reirradiation for Patients With Recurrent Head and Neck Squamous Cell Carcinoma

Radiotherapy and paclitaxel plus pazopanib or placebo in anaplastic thyroid cancer (NRG/RTOG 0912): a randomised, double-blind, placebo-controlled, multicentre, phase 2 trial

Analysis of Tumor Mutational Burden, Progression-Free Survival, and Local-Regional Control in Patients with Locally Advanced Non-Small Cell Lung Cancer Treated With Chemoradiation and Durvalumab

A macrophage-activated abscopal effect

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Oropharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy

Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus-associated oropharyngeal cancer

Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma

Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity

Prognostic impact of extranodal extension (ENE) in surgically managed treatment-naive HPV-positive oropharyngeal squamous cell carcinoma with nodal metastasis

Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology

A Pilot Study of Durvalumab (MEDI4736) with Tremelimumab in Combination with Image-Guided Stereotactic Body Radiotherapy in the Treatment of Metastatic Anaplastic Thyroid Cancer

Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids

Effects of Tumor Mutational Burden and Gene Alterations Associated with Radiation Response on Outcomes of Postoperative Radiation Therapy in Non-Small Cell Lung Cancer

Evaluation of Substantial Reduction in Elective Radiotherapy Dose and Field in Patients With Human Papillomavirus-Associated Oropharyngeal Carcinoma Treated With Definitive Chemoradiotherapy

Cancer-Causative Mutations Occurring in Early Embryogenesis

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

Current considerations for radiotherapy in HPV-associated head and neck cancer

The effect of short radiation treatment breaks on chemo-radiotherapy for oropharyngeal cancers

TERT Promoter Mutations Are Enriched in Oral Cavity Cancers and Associated With Locoregional Recurrence

Intensity-modulated radiation therapy and doxorubicin in thyroid cancer: A prospective phase 2 trial

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy

Tumor Immunity and Immunotherapy for HPV-Related Cancers

Reproducibility of radiomic features using network analysis and its application in Wasserstein k-means clustering

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer

Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Synthetic Lethality in Cancer Therapeutics: The Next Generation

Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women

Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy

Any day, split halfway: Flexibility in scheduling high-dose cisplatin-A large retrospective review from a high-volume cancer center

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

Precision Radiotherapy: Reduction in Radiation for Oropharyngeal Cancer in the 30 ROC Trial