Riaz Lab
Our lab elucidates how defects in DNA repair influence anti-cancer immunity and, in turn, expand opportunities to personalize widely used cancer therapies such as radiotherapy. We pair computational analyses of human‑tumor datasets with murine and cellular models to identify causal, clinically relevant biology. Our group is a diverse multidisciplinary team of computational biologists, wet-lab scientists, and clinical trialists working in unison toward this goal.
Updates
New Nat Cancer study links intratumoral microbiome and tumor ecosystem features with response and resistance to immune checkpoint blockade plus chemoradiotherapy in head and neck cancer.
DDR ↔ Immunity
We study how defects in homologous recombination DNA repair influence immune surveillance, revealing that mutations in different nodes of the pathway have distinct immunologic outcomes.
Mutational Signatures
Mutational signature analysis uncovers pan-cancer DNA repair phenotypes and nominates new vulnerabilities.
Precision Radiotherapy
Translational studies identify which HPV-positive patients can safely receive markedly reduced-dose chemoradiation.
