Riaz Lab · Memorial Sloan Kettering · New York
Our lab elucidates how defects in DNA repair influence anti-cancer immunity and, in turn, expand opportunities to personalize widely used cancer therapies such as radiotherapy. We pair computational analyses of human-tumor datasets with murine and cellular models to identify causal, clinically relevant biology. Our group is a diverse multidisciplinary team of computational biologists, wet-lab scientists, and clinical trialists working in unison toward this goal.
Updates
Nadeem goes on a head and neck cancer podcast to discuss recent findings published in Nature Cancer on how intra-tumor bacteria influence the combination of immunotherapy with radiotherapy.
Research areas
We work across scales, from single-cell computational analysis of human tumors to murine models and investigator-initiated clinical trials, to convert causal DDR-immune biology into precision therapies.
We study how defects in homologous recombination DNA repair influence immune surveillance, revealing that mutations in different nodes of the pathway have distinct immunologic outcomes.
Learn more →Mutational SignaturesMutational signature analysis uncovers pan-cancer DNA repair phenotypes and nominates new vulnerabilities.
Learn more →Precision RadiotherapyTranslational studies identify which HPV-positive patients can safely receive markedly reduced-dose chemoradiation.
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